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Synthesis, in Vitro Hydroxyapatite Forming Ability, and Cytocompatibility of Strontium Silicate Powders by Meili Zhang; Wanyin Zhai; Kaili Lin; Haobo Pan; William Lu; Jiang Chang is a Medicine article available to read on EtoBox.

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## Abstract Phase‐pure strontium silicate (SrSiO~3~) powders were synthesized by chemical precipitation method. __In vitro__ bioactivity of the powders were evaluated by examining the hydroxyapatite forming ability on their surface soaking simulated body fluid for various periods. The results showed that SrSiO~3~ could induce hydroxy carbonate apatite formation after soaking for 7 days. Both L929 and rabbit bone marrow stromal cells (rMSCs) were used to test the __in vitro__ cytocompatibility of SrSiO~3~. L929 culture experiment showed that the ionic product of SrSiO~3~ did not exhibit cytotoxicity except at high ion concentrations (Si 3.75 m__M__ and Sr 0.12 m__M__). Moreover, at certain ion concentrations (Si 1.87–0.12 m__M__ and Sr 0.12–3.75 × 10^−3^ m__M__), the ionic product of SrSiO~3~ stimulated the proliferation of rMSCs. All the results indicated that SrSiO~3~ might be used as a new bioactive material for bone regeneration applications. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010

Who reads Synthesis, in Vitro Hydroxyapatite Forming Ability, and Cytocompatibility of Strontium Silicate Powders?

Author

Meili Zhang; Wanyin Zhai; Kaili Lin; Haobo Pan; William Lu; Jiang Chang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1552-4973)

Published

2010

Language

EN

Field

Medicine (Health Sciences)