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Can I read A Prognostic Insight on in Vivo Expression of Interleukin-6 in Uterine Cervical Cancer on EtoBox?
A Prognostic Insight on in Vivo Expression of Interleukin-6 in Uterine Cervical Cancer by R. Srivani; B. Nagarajan is a Medicine article available to read on EtoBox.
What is A Prognostic Insight on in Vivo Expression of Interleukin-6 in Uterine Cervical Cancer about?
Interleukin-6 (IL-6) is a multifunctional cytokine with a growth promoting role in cancers. In an attempt to evaluate the prognostic significance of IL-6, we have studied the localization of this cytokine by immunohistochemical methods in normal, premalignant, and invasive cervical cancers. We stained frozen sections with a monoclonal antibody specific for human IL-6 and demonstrated that tumor cells show positivity with high intensity and stromal cells with moderate intensity. T cells and macrophages, components of the stroma that secrete IL-6, were also looked at. While T cells showed a weak positive correlation, CD68-positive macrophages showed significant positive correlation (P < 0.05) with IL-6 positivity in stroma. The patients were followed up for 40 months after treatment with standard radiotherapy regimen and showed residual tumor where pretreatment IL-6 levels were high. Our results suggest its possible candidature as a prognostic indicator of cervical cancer.
Who reads A Prognostic Insight on in Vivo Expression of Interleukin-6 in Uterine Cervical Cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- R. Srivani; B. Nagarajan
- Publisher
- John Wiley and Sons; BMJ; Wolters Kluwer Health; Ovid Technologies (Wolters Kluwer Health) (ISSN 1048-891X)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)