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Dermal Pharmacokinetics of the Insecticide Furathiocarb in Rats by Kwang-Hyeon Liu; Ha-Jung Sung; Hae-Keun Lee; Byung-Hun Song; Yang-Bin Ihm; Kyun Kim; Hye-Suk Lee; Jeong-Han Kim is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Dermal Pharmacokinetics of the Insecticide Furathiocarb in Rats about?
## Abstract The pharmacokinetics of furathiocarb were studied __in vivo__ in male Sprague–Dawley rats following dermal treatment. HPLC and post‐column derivatization were used for the analysis of furathiocarb and its metabolites (carbofuran, 3‐hydroxycarbofuran and 3‐ketocarbofuran). Carbofuran and 3‐hydroxycarbofuran were detected in plasma and urine rather than furathiocarb. 3‐Ketocarbofuran, another potential metabolite, was not observed in any sample. The concentration of carbofuran was higher than that of 3‐hydroxycarbofuran in plasma, but the reverse was the case in urine. The corresponding area under the plasma concentration–time curve, __T__~max~, and __C__~max~ values of carbofuran and 3‐hydroxycarbofuran for 1500 mg kg^−1^ doses were 2.4–8.0 mg equiv h ml^−1^, 12 h and 0.1–0.4 mg equiv ml^−1^, respectively. __T__~1/2~ was calculated only for 3‐hydroxycarbofuran (28 h). Two metabolites were excreted in a dose‐dependent manner without saturation. © 2001 Society of Chemical Industry
Who reads Dermal Pharmacokinetics of the Insecticide Furathiocarb in Rats?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Kwang-Hyeon Liu; Ha-Jung Sung; Hae-Keun Lee; Byung-Hun Song; Yang-Bin Ihm; Kyun Kim; Hye-Suk Lee; Jeong-Han Kim
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1526-498X)
- Published
- 2001
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)