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Can I read Lnc-17Rik promotes the immunosuppressive function of Myeloid-Derived suppressive cells in esophageal cancer on EtoBox?
Lnc-17Rik promotes the immunosuppressive function of Myeloid-Derived suppressive cells in esophageal cancer by Jiexia Wen; Bin Xuan; Yunhuan Gao; Yang Liu; Liwei Wang; Li He; Xiangcai Meng; Tao Zhou; Yang Tao; Kening Guo; Yimin Wang is a Immunology and Microbiology article available to read on EtoBox.
What is Lnc-17Rik promotes the immunosuppressive function of Myeloid-Derived suppressive cells in esophageal cancer about?
Myeloid-derived suppressor cells (MDSCs) are a population of immature bone marrow cells that accumulate in large numbers in the spleen, peripheral blood, bone marrow, lymph nodes, and local and metastatic foci of tumors. C/EBP homologous protein (CHOP) and CCAAT/enhancer binding protein β (C/EBPβ) play key roles in regulating the immunosuppressive function and differentiation of MDSCs. Our study revealed that the long noncoding RNA Lnc-17Rik was able to promote immunosuppression in tumors by facilitating the activation and expression of key genes involved in MDSC differentiation. Lnc-17Rik was shown to directly interact with CHOP and C/EBPβ LIP to facilitate their dissociation from the transcriptional repressor complex involving C/EBP LAP/LIP/CHOP. Moreover, Lnc-17Rik increased the association of WD repeat-containing protein 5 (WDR5) with C/EBP LAP, promoting H3K4me3 enrichment in the promoter regions of arginase 1 (Arg-1), cyclooxygenase 2 (COX2), nitric oxide synthase 2 (NOS2) and NADPH oxidase 2 (NOX2) to enhance the expression of these genes. Furthermore, using a CD45 chimeric model we confirmed that Lnc-17Rik promoted the differentiation of monocytic (M)-MDSCs in vivo with the
Who reads Lnc-17Rik promotes the immunosuppressive function of Myeloid-Derived suppressive cells in esophageal cancer?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Jiexia Wen; Bin Xuan; Yunhuan Gao; Yang Liu; Liwei Wang; Li He; Xiangcai Meng; Tao Zhou; Yang Tao; Kening Guo; Yimin Wang
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)