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Lama1 Mutations Lead to Vitreoretinal Blood Vessel Formation, Persistence of Fetal Vasculature, and Epiretinal Membrane Formation in Mice by Malia M Edwards; D Scott McLeod; Rhonda Grebe; Céline Heng; Olivier Lefebvre; Gerard A Lutty is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background Valuable insights into the complex process of retinal vascular development can be gained using models with abnormal retinal vasculature. Two such models are the recently described mouse lines with mutations in __Lama1__, an important component of the retinal internal limiting membrane (ILM). These mutants have a persistence of the fetal vasculature of vitreous (FVV) but lack a primary retinal vascular plexus. The present study provides a detailed analysis of astrocyte and vascular development in these __Lama1__ mutants. ## Results Although astrocytes and blood vessels initially migrate into __Lama1__ mutant retinas, both traverse the peripapillary ILM into the vitreous by P3. Once in the vitreous, blood vessels anastomose with vessels of the vasa hyaloidea propria, part of the FVV, and eventually re-enter the retina where they dive to form the inner and outer retinal capillary networks. Astrocytes continue proliferating within the vitreous to form a dense mesh that resembles epiretinal membranes associated with persistent fetal vasculature and proliferative vitreoretinopathy. ## Conclusions __Lama1__ and a fully intact ILM are required for normal retinal vascular deve

Who reads Lama1 Mutations Lead to Vitreoretinal Blood Vessel Formation, Persistence of Fetal Vasculature, and Epiretinal Membrane Formation in Mice?

Author

Malia M Edwards; D Scott McLeod; Rhonda Grebe; Céline Heng; Olivier Lefebvre; Gerard A Lutty

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-213X)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)