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Can I read Proteome Profiles of Mucosal Immunoglobulin Uptake in Inflamed Porcine Gut on EtoBox?
Proteome Profiles of Mucosal Immunoglobulin Uptake in Inflamed Porcine Gut by Marianne Danielsen; Thomas Thymann; Bent Borg Jensen; Ole Nørregaard Jensen; Per Torp Sangild; Emøke Bendixen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Proteome Profiles of Mucosal Immunoglobulin Uptake in Inflamed Porcine Gut about?
Acquisition of passive immunity by endocytosis of intact immunoglobulins (Ig) from colostrum is critical for prevention of intestinal and systemic diseases in neonatal mammals. We compared proteome patterns of healthy and inflamed gut tissues from pre-term piglets to investigate the effect of inflammation on acquisition of passive immunity. A clear difference in the two-dimensional gel electrophoresis protein patterns between healthy and inflamed intestinal tissues was observed, suggesting that inflamed tissues failed to absorb and transfer Ig from colostrum to epithelial cells. We have mapped and identified the Ig proteins that are taken up by healthy intestinal tissues, and found that isoforms of the IgA and IgG heavy chain and Ig kappa and lambda light chains were internalized. Our results indicate that colostrum protein uptake in the porcine gut is a selective process that is obstructed in inflamed pre-term gut.
Who reads Proteome Profiles of Mucosal Immunoglobulin Uptake in Inflamed Porcine Gut?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Marianne Danielsen; Thomas Thymann; Bent Borg Jensen; Ole Nørregaard Jensen; Per Torp Sangild; Emøke Bendixen
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 1615-9853)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)