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Wastewater‐derived antagonistic activities of G protein‐coupled receptor‐acting pharmaceuticals in river water by Masaru Ihara; Seiya Hanamoto; Mariko O. Ihara; Han Zhang; Hiroaki Tanaka is a Environmental Science article available to read on EtoBox.

What is Wastewater‐derived antagonistic activities of G protein‐coupled receptor‐acting pharmaceuticals in river water about?

Pharmaceuticals are widely detected in aquatic environments, and their potential risks to aquatic species are of concern because they are designed to be biologically active. Here, we used an in vitro assay, called the transforming growth factor α shedding assay, to measure the biological activities of G protein-coupled receptor (GPCR)-acting pharmaceuticals present in river water and effluents from municipal wastewater treatment plants (WWTPs) in Japan from 2014 to 2016. Antagonistic activities against angiotensin (AT1), dopamine (D2), adrenergic (β1), acetylcholine (M1) and histamine (H1) receptors were detected in river water, and were stronger downstream than upstream owing to effluent from WWTPs along the river. Ozonation at one WWTP reduced these activities. Concentrations of sulpiride (D2 antagonist) could explain 73% of antagonistic activities against the D2 receptor; those of metoprolol, atenolol and propranolol (β1 antagonists) could explain 16% of activities against the β1 receptor; and those of pirenzepine (M1 antagonist) could explain 15% of activities against the M1 receptor. Therefore, other receptor antagonists also occur. GPCR-acting pharmaceuticals should be given

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Author

Masaru Ihara; Seiya Hanamoto; Mariko O. Ihara; Han Zhang; Hiroaki Tanaka

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0260-437X)

Published

2020

Language

EN

Field

Environmental Science (Physical Sciences)