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This research article investigates the immunogenicity of avian influenza virus (AIV) antigens encapsulated in PLGA nanoparticles, focusing on both mucosal and subcutaneous delivery methods in chickens. The studies found that the inclusion of CpG ODN as an adjuvant significantly enhanced antibody responses, with chitosan-coated nanoparticles producing higher levels of specific antibodies compared to mannan-coated ones. Overall, the findings suggest that PLGA nanoparticle-based vaccines can effectively induce

Author
Kuantai
Language
EN