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Can I read Oxidative Stress: A Unifying Paradigm in Hypertension on EtoBox?
Oxidative Stress: A Unifying Paradigm in Hypertension by Rhian M. Touyz; Francisco J. Rios; Rhéure Alves-Lopes; Karla B. Neves; Livia L. Camargo; Augusto C. Montezano is a Medicine article available to read on EtoBox.
What is Oxidative Stress: A Unifying Paradigm in Hypertension about?
The etiology of hypertension involves complex interactions among genetic, environmental, and pathophysiologic factors that influence many regulatory systems. Hypertension is characteristically associated with vascular dysfunction, cardiovascular remodelling, renal dysfunction, and stimulation of the sympathetic nervous system. Emerging evidence indicates that the immune system is also important and that activated immune cells migrate and accumulate in tissues promoting inflammation, fibrosis, and target-organ damage. Common to these processes is oxidative stress, defined as an imbalance between oxidants and antioxidants in favour of the oxidants that leads to a disruption of oxidation-reduction (redox) signalling and control and molecular damage. Physiologically, reactive oxygen species (ROS) act as signalling molecules and influence cell function through highly regulated redox-sensitive signal transduction. In hypertension, oxidative stress promotes posttranslational modification (oxidation and phosphorylation) of proteins and aberrant signalling with consequent cell and tissue damage. Many enzymatic systems generate ROS, but NADPH oxidases (Nox) are the major sources in cells of
Who reads Oxidative Stress: A Unifying Paradigm in Hypertension?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Rhian M. Touyz; Francisco J. Rios; Rhéure Alves-Lopes; Karla B. Neves; Livia L. Camargo; Augusto C. Montezano
- Publisher
- Pulsus Group Inc; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0828-282X)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)