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Can I read Conventional Induction Treatments Do Not Influence Overall Survival in Multiple Myeloma on EtoBox?
Conventional Induction Treatments Do Not Influence Overall Survival in Multiple Myeloma by MARIO BOCCADORO; ANTONIO PALUMBO; CHIARA ARGENTINO; ALIDA DOMINIETTO; ROBERTO FRIERI; GIUSEPPE AVVISATI; BENEDETTO COMOTTI; VITO MICHELE LAUTA; MARINA LIBERATI; FILIPPO MARMONT; PELLEGRINO MUSTO; MAURIZIO TRIBALTO; ALESSANDRO PILERI is a Medicine article available to read on EtoBox.
What is Conventional Induction Treatments Do Not Influence Overall Survival in Multiple Myeloma about?
A retrospective analysis was performed on two subsequent myeloma patient series treated with the same conventional induction treatments, melphalan and prednisone or alternating VMCP/VBAP: 273 were enrolled in the multicentre M83 trial (M83 trial group) from 1983 to 1986; 160 were referred to a single institution (Haemat.To group) from 1986 to 1994. Response to treatment was very similar in the two groups (53% __v__ 50.3%). Remission duration curves merely overlapped (median 20 __v__ 21 months). However, overall survival was significantly longer in the Haemat.To group (43.2 __v__ 33 months, __P__ < 0.04). This difference was due to a prolonged period from relapse or progression to death (21 __v__ 8 months, __P__ < 0.01; 20.8 __v__ 7 months, __P__ 3 mg/l, in the Haemat.To group (31.8 __v__ 24.2 months, __P__ < 0.04). The same induction treatments produced almost identical response rate and remission duration in both groups, but overall survival was 10 months longer for one group. However, it could be argued that treatment salvage modalities and support therapies have been improved in a decade. Lastly, induction treatments did not influence overall survival.
Who reads Conventional Induction Treatments Do Not Influence Overall Survival in Multiple Myeloma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- MARIO BOCCADORO; ANTONIO PALUMBO; CHIARA ARGENTINO; ALIDA DOMINIETTO; ROBERTO FRIERI; GIUSEPPE AVVISATI; BENEDETTO COMOTTI; VITO MICHELE LAUTA; MARINA LIBERATI; FILIPPO MARMONT; PELLEGRINO MUSTO; MAURIZIO TRIBALTO; ALESSANDRO PILERI
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)