Can I read Editorial: Sirtuins From Bench to Bedside: How Far Are We? on EtoBox?

Editorial: Sirtuins From Bench to Bedside: How Far Are We? by Jose Thaiparambil is a Medicine article available to read on EtoBox.

What is Editorial: Sirtuins From Bench to Bedside: How Far Are We? about?

Editorial on the Research Topic Sirtuins from Bench to Bedside: How Far Are We?Sirtuins (SIRT1-7) regulate diverse physiological processes including metabolism, oxidative stress, DNA repair, protein synthesis, inflammation, and cell death. Recent literature shows that dysregulation of sirtuins could lead to heart failure, neurological disorders, and cancer. However, the mechanisms of sirtuin regulation in diverse cellular processes and their clinical utility are not well understood; five reviews and a research report examining these topics are discussed here.Watroba and Szukiewicz focused on the involvement of sirtuins in neurodegeneration, the inflammatory response, metabolic syndrome, DNA damage, and genomic instability as hallmarks of aging and cancer incidence. It explains that caloric restriction could play a role in anti-aging by activating sirtuins, which stimulate nicotinamide adenine dinucleotide (NAD+) biosynthesis, raising the level of intracellular NAD+. This is a hot topic due to public and scientific interest in caloric restriction to reduce body weight and slow aging and associated diseases. SIRT1 induction in neurons results in mTOR inhibition that promotes neurite

Who reads Editorial: Sirtuins From Bench to Bedside: How Far Are We??

Author

Jose Thaiparambil

Publisher

Frontiers Media SA

Published

2022

Language

EN

Field

Medicine (Health Sciences)