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The article discusses the unexpected C-2 selectivity of Grignard additions to N-Boc-protected isatin 3-imines, resulting in the formation of 3-imino-2-phenethylindolin-2-ols. The study highlights the influence of protecting groups on chemoselectivity, with different protecting groups leading to C-3 addition products. Additionally, the synthesized compounds exhibited antiplasmodial activity against Plasmodium falciparum strains, indicating potential for further pharmacological exploration.

Author

agbobenita2022

Language

EN