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Progressive Worsening of Gait and Motor Abnormalities in Older Adults With Dravet Syndrome by Arunan Selvarajah; Carolina Gorodetsky; Paula Marques; Quratulain Zulfiqar Ali; Anne T. Berg; Alfonso Fasano; Danielle M. Andrade is a Medicine article available to read on EtoBox.

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## Background and Objectives Relative to the pediatric population, there is limited information about Dravet syndrome (DS) in adults. In addition to some of the gait abnormalities reported in children with DS (such as crouch gait and ataxia), adults with this condition have other gait and motor disturbances. Our primary objective was to examine gait and motor manifestations in adults with DS. ## Methods This study includes a prospective arm where 6 patients (mean age, 32 years) were examined through a modified version of the Unified Parkinson's Disease Rating Scale (mUPDRS) in 2014 and again in 2019. mUPDRS scores were assigned to gait, resting tremors, facial expression, arising from a chair, posture, and body bradykinesia. The cross-sectional arm includes mUPDRS testing in patients who were not evaluated in 2014 and an instrumental gait analysis (IGA). These cross-sectional tests were done in the 2019–2020 period. The IGA was performed using ProtoKinetics software with a gait mat built with sensors and 2 cameras capturing the sagittal and coronal planes. The IGA was performed in a group of 17 patients with DS (mean age, 31 years); the control group consisted of 81 healthy individ

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Author

Arunan Selvarajah; Carolina Gorodetsky; Paula Marques; Quratulain Zulfiqar Ali; Anne T. Berg; Alfonso Fasano; Danielle M. Andrade

Published

2022

Language

EN

Field

Medicine (Health Sciences)