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Intranasal Tetrandrine Temperature-sensitive in Situ Hydrogels for the Treatment of Microwave-induced Brain Injury by Lihua Zhang; Lulu Pang; Siqing Zhu; Jinqiu Ma; Ruiteng Li; Yijing Liu; Lin Zhu; Xiaomei Zhuang; Weijia Zhi; Xiang Yu; Lina Du; Hongyan Zuo; Yiguang Jin is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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The brain is the most sensitive organ to microwave radiation. However, few effective drugs are available for the treatment of microwave-induced brain injury due to the poor drug permeation into the brain. Here, intranasal tetrandrine (TET) temperature-sensitive in situ hydrogels (ISGs) were prepared with poloxamers 407 and 188. Its characteristics were evaluated, including rheological properties, drug release in vitro, and mucosal irritation. The pharmacodynamics and brain-targeting effects were also studied. The highly viscous ISGs remained in the nasal cavity for a long time with the sustained release of TET and no obvious ciliary toxicity. Intranasal temperature-sensitive TET ISGs markedly improved the spatial memory and spontaneous exploratory behavior induced by microwave with the Morris water maze (MWM) and the open field test (OFT) compared to the model. The ISGs alleviated the microwave-induced brain damage and inhibited the certain mRNA expressions of calcium channels in the brain. Intranasal temperature-sensitive TET ISGs was rapidly absorbed with a shorter T (4.8 h) compared to that of oral TET (8.4 h). The brain targeting index of intranasal temperature-sensitive TET IS

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Author

Lihua Zhang; Lulu Pang; Siqing Zhu; Jinqiu Ma; Ruiteng Li; Yijing Liu; Lin Zhu; Xiaomei Zhuang; Weijia Zhi; Xiang Yu; Lina Du; Hongyan Zuo; Yiguang Jin

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2020

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)