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Macrophage — T-lymphocyte interaction in lichen planus: An electron microscopic and immunocytochemical study by Benvenuto Giannotti; Giuseppe De Panfilis; Gian Carlo Manara; Fulvio Allegra is a Medicine article available to read on EtoBox.

What is Macrophage — T-lymphocyte interaction in lichen planus: An electron microscopic and immunocytochemical study about?

Papular lichen planus lesions from 12 patients were studied by a double-step immunocytochemical method to detect T-lymphocytes. Semithin sections were studied by light microscopy and ultrathin sections examined by electron microscopy. In the dermal infiltrate, many T-lymphocytes appeared closely juxtaposed to macrophages or Langerhans cells, frequently arranged in a rosette-like pattern. In the epidermis, T-lymphocytes were juxtaposed to macrophages or Langerhans cells and to degenerated keratinocytes. The close relationship between T-lymphocytes, macrophages or Langerhans cells and degenerated keratinocytes supports the hypothesis that lichen planus is immunological in nature: T-lymphocytes, after interacting with macrophages or Langerhans cells, become cytotoxic for keratinocytes.

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Author

Benvenuto Giannotti; Giuseppe De Panfilis; Gian Carlo Manara; Fulvio Allegra

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0340-3696)

Published

1982

Language

EN

Field

Medicine (Health Sciences)