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Electrocardiographic changes in the acute hyperkalaemia produced by intragastric KCl load in rats by Frederico Fazan; Débora Simões de Almeida Colombari; José Vanderlei Menani; Rubens Fazan; Eduardo Colombari is a Medicine article available to read on EtoBox.

What is Electrocardiographic changes in the acute hyperkalaemia produced by intragastric KCl load in rats about?

## New Findings What is the central question of this study? This study presents a new model for studying the rapid onset of severe, acute hyperkalaemia in rats with intact kidney function by administering an intragastric KCl load. What is the main finding and its importance? This new model of intragastric KCl load produces a reliable and reproducible model for studying the rapid onset of severe, acute hyperkalaemia in rats with intact kidney function. We report unprecedented rapid changes (30 min) in ECG, blood pressure and various arterial blood analyses with this new model, providing a solid foundation for future experiments in this field. ## Abstract A variety of animal models have been proposed to study hyperkalaemia, but most of them have meaningful limitations when the goal is to study the effect of potassium overload on healthy kidneys. In this study, we aimed to introduce a new approach for induction of hyperkalaemia in a reliable and reproducible animal model. We used intragastric administration of potassium chloride [KCl 2.3 M, 10 ml/(kg body weight)] to male Holtzman rats (300–350 g) to induce hyperkalaemia. The results showed that this potassium load can temporarily ove

Who reads Electrocardiographic changes in the acute hyperkalaemia produced by intragastric KCl load in rats?

Author

Frederico Fazan; Débora Simões de Almeida Colombari; José Vanderlei Menani; Rubens Fazan; Eduardo Colombari

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)