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The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion by Mitsutoshi Nakada; Eric M. Anderson; Tim Demuth; Satoko Nakada; Linsey B. Reavie; Kelsey L. Drake; Dominique B. Hoelzinger; Michael E. Berens is a Medicine article available to read on EtoBox.
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## Abstract To reveal molecular drivers of glioma invasion, two distinct glioblastoma (GBM) cell phenotypes (invading cells and tumor core cells) were collected from 19 GBM specimens using laser capture microdissection. Isolated RNA underwent whole human genome expression profiling to identify differentially expressed genes. Pathway enrichment analysis highlighted the bidirectional receptor/ligand tyrosine kinase system, EphB/ephrin‐B, as the most tightly linked system to the invading cell phenotype. Clinical relevance of ephrin‐B genes was confirmed in a clinically annotated expression data set of 195 brain biopsy specimens. Levels of ephrin‐B1 and ‐B2 mRNA were significantly higher in GBM (__n__ = 82) than in normal brain (__n__ = 24). Kaplan–Meier analysis demonstrated ephrin‐B2, but not ephrin‐B1, expression levels were significantly associated with short term survival in malignant astrocytomas (__n__ = 97, __p__ = 0.016). In human brain tumor specimens, the production and phosphorylation of ephrin‐B2 were high in GBM. Immunohistochemistry demonstrated ephrin‐B2 localization primarily in GBM cells but not in normal brain. A highly invasive glioma cell line, U87, expressed high
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- Author
- Mitsutoshi Nakada; Eric M. Anderson; Tim Demuth; Satoko Nakada; Linsey B. Reavie; Kelsey L. Drake; Dominique B. Hoelzinger; Michael E. Berens
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)