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Can I read Influences of Renal Insufficiency and Ischemia on Mitochondrial Bioenergetics and Limb Dysfunction in a Novel Murine Iliac Arteriovenous Fistula Model on EtoBox?
Influences of Renal Insufficiency and Ischemia on Mitochondrial Bioenergetics and Limb Dysfunction in a Novel Murine Iliac Arteriovenous Fistula Model by Erik M. Anderson; Kyoungrae Kim; Brian J. Fazzone; Kenneth C. Harland; Qiongyao Hu; Zach Salyers; Victoria R. Palzkill; Tomas A. Cort; Eric M. Kunz; Andrew J. Martin; Dan Neal; Kerri A. O’Malley; Scott A. Berceli; Terence E. Ryan; Salvatore T. Scali is a Medicine article available to read on EtoBox.
What is Influences of Renal Insufficiency and Ischemia on Mitochondrial Bioenergetics and Limb Dysfunction in a Novel Murine Iliac Arteriovenous Fistula Model about?
## Objective Hand disability after hemodialysis access surgery has been common yet has remained poorly understood. Arteriovenous fistula (AVF) hemodynamic perturbations have not reliably correlated with the observed measures of hand function. Chronic kidney disease (CKD) is known to precipitate myopathy; however, the interactive influences of renal insufficiency and ischemia on limb outcomes have remained unknown. We hypothesized that CKD would contribute to access-related hand dysfunction via altered mitochondrial bioenergetics. Using a novel murine AVF model, we sought to characterize the skeletal muscle outcomes in mice with and without renal insufficiency. ## Methods Male, 8-week-old C57BL/6J mice were fed either an adenine-supplemented diet to induce renal insufficiency (CKD) or a casein-based control chow (CON). After 2 weeks of dietary intervention, the mice were randomly assigned to undergo iliac AVF surgery (n = 12/group) or a sham operation (n = 5/group). Measurements of aortoiliac hemodynamics, hindlimb perfusion, and hindlimb motor function were collected for 2 weeks. The mice were sacrificed on postoperative day 14 to assess skeletal muscle histopathologic features and
Who reads Influences of Renal Insufficiency and Ischemia on Mitochondrial Bioenergetics and Limb Dysfunction in a Novel Murine Iliac Arteriovenous Fistula Model?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Erik M. Anderson; Kyoungrae Kim; Brian J. Fazzone; Kenneth C. Harland; Qiongyao Hu; Zach Salyers; Victoria R. Palzkill; Tomas A. Cort; Eric M. Kunz; Andrew J. Martin; Dan Neal; Kerri A. O’Malley; Scott A. Berceli; Terence E. Ryan; Salvatore T. Scali
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)