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Social Factors and Individual Vulnerability to Chronic Stress Exposure by Alessandro Bartolomucci; Paola Palanza; Paola Sacerdote; Alberto E. Panerai; Andrea Sgoifo; Robert Dantzer; Stefano Parmigiani is a Neuroscience article available to read on EtoBox.

What is Social Factors and Individual Vulnerability to Chronic Stress Exposure about?

The stress-response is adaptive in the short-term, but it can be maladaptive if sustained levels of its mediators are chronically maintained. Furthermore, not all individuals exposed to chronic stress will progress to disease. Thus, understanding the causes of individual differences and the consequences of variation in vulnerability is of major importance. The aim of this review is to shed light on this issue by presenting a new naturalistic model of chronic psychosocial stress in male mice. Resident/intruder pairs of mice lived in continuous sensory contact and physically interacted daily. Four categories were identified: Resident Dominant, Resident Subordinate (RS), Intruder Dominant, and Intruder Subordinate. Behavior, autonomic and immune functions, hypothalamic-pituitary-adrenocortical responses, brain cytokine expression and cardiac histology were investigated in stress-exposed mice. Certain stress-induced alterations were present in all mice independent of their social status, while others clearly differentiated dominants from subordinates. RS mice showed a unique profile of alterations suggesting that the loss of relevant resources, such as the territory, is the key factor

Who reads Social Factors and Individual Vulnerability to Chronic Stress Exposure?

Author

Alessandro Bartolomucci; Paola Palanza; Paola Sacerdote; Alberto E. Panerai; Andrea Sgoifo; Robert Dantzer; Stefano Parmigiani

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0149-7634)

Published

2005

Language

EN

Field

Neuroscience (Life Sciences)