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Can I read Impact on cholinesterase-inhibition and in silico investigations of sesquiterpenoids from Amazonian Siparuna guianensis Aubl. on EtoBox?
Impact on cholinesterase-inhibition and in silico investigations of sesquiterpenoids from Amazonian Siparuna guianensis Aubl. by Regildo M.G. Martins; Francisco H. Xavier-Júnior; Marcela R. Barros; Thaís M. Menezes; Caio R.D. de Assis; Ana Cristina G.R. de Melo; Bruno O. Veras; Vany P. Ferraz; Antonio A.M. Filho; Gilvan T. Yogui; Ranilson S. Bezerra; Gustavo M. Seabra; Jorge L. Neves; Wanderli P. Tadei is a Chemistry article available to read on EtoBox.
What is Impact on cholinesterase-inhibition and in silico investigations of sesquiterpenoids from Amazonian Siparuna guianensis Aubl. about?
The plant popularly known as "negramina" (Siparuna guianensis Aubl.), member of the family Siparunaceae produces an essential oil that presents several biological activities reported in literature. Here, the essential oil was obtained by hydrodistillation from fresh leaves collected in the state of Roraima, far north of the Amazon. Chemical composition of the essential oil was characterized by gas chromatography coupled to mass spectrometry (GC-MS) and flame ionization detector (GC-FID). The sesquiterpenoid shyobunone and its derivatives were identified as major compounds in the oil (>40%). The effect of S. guianensis essential oil on the acetylcholinesterase (AChE) activity from Crassostrea rhizophorae, Litopenaeus vannamei and Electrophorus electricus was tested by spectrophotometric assays. The essential oil has been identified as an AChE inhibitor. The mechanism of inhibition was investigated as well as spectrofluorimetric interactions between the essential oil and the enzyme. H NMR titration and molecular docking were also investigated. The spectrophotometric results revealed that shyobunone and its derivatives strongly interact with AChE with a kind of non-competitive inhibit
Who reads Impact on cholinesterase-inhibition and in silico investigations of sesquiterpenoids from Amazonian Siparuna guianensis Aubl.?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Regildo M.G. Martins; Francisco H. Xavier-Júnior; Marcela R. Barros; Thaís M. Menezes; Caio R.D. de Assis; Ana Cristina G.R. de Melo; Bruno O. Veras; Vany P. Ferraz; Antonio A.M. Filho; Gilvan T. Yogui; Ranilson S. Bezerra; Gustavo M. Seabra; Jorge L. Neves; Wanderli P. Tadei
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Chemistry (Physical Sciences)