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Germ‐Free mice are not protected against diet‐induced obesity and metabolic dysfunction by Moretti, Chiara H; Schiffer, Tomas A; Li, Xuechen; Weitzberg, Eddie; Carlström, Mattias; Lundberg, Jon O is a Medicine article available to read on EtoBox.
What is Germ‐Free mice are not protected against diet‐induced obesity and metabolic dysfunction about?
## Aim: Studies in the past 15 years have highlighted the role of the gut microbiota in modulation of host metabolism. the observation that germ-free (gf) mice are leaner than conventionally raised (conv) mice and their apparent resistance to diet-induced obesity (dio), sparked the interest in dissecting the possible causative role of the gut microbiota in obesity and metabolic diseases. however, discordant results among studies leave such relationship elusive. in this study, we compared the effects of chronic western diet (wd) intake on body weight and metabolic function of gf and conv mice. ## Methods: We fed gf and conv mice a wd for 16 weeks and monitored body weight weekly. at the end of the dietary challenge, the metabolic phenotype of the animals was assessed. muscle carnitine palmitoyltransferase i (cpt1) and liver ampk activation were investigated. ## Results: Both gf and conv mice gained weight and developed glucose intolerance when fed a wd. moreover, wd feeding was associated with increased adipose tissue inflammation, repressed hepatic ampk activity, fatty liver and elevated hepatic triglycerides in both groups of mice. enhanced fatty acid oxidation in the gf mouse is
Who reads Germ‐Free mice are not protected against diet‐induced obesity and metabolic dysfunction?
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- Author
- Moretti, Chiara H; Schiffer, Tomas A; Li, Xuechen; Weitzberg, Eddie; Carlström, Mattias; Lundberg, Jon O
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; John Wiley and Sons Ltd; Wiley (ISSN 1748-1708)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)