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What is Oxygen Homeostasis and Hypoxia Signaling about?
This document summarizes recent discoveries about the molecular mechanisms that regulate responses to hypoxia (low oxygen levels) in organisms. It describes how hypoxia-inducible factors (HIFs) transduce transcriptional responses to hypoxia by regulating hundreds to thousands of target genes. The key oxygen-sensitive mechanism involves prolyl hydroxylases that hydroxylate HIF proteins in the presence of oxygen, targeting them for degradation; under hypoxia, this is suppressed, stabilizing HIFs. One importan
- Author
- abdul88f
- Language
- EN