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Transvascular and interstitial transport in rat hepatocellular carcinomas: Dynamic contrast‐enhanced MRI assessment with low‐ and high‐molecular weight agents by Nicolas Michoux; Laurent Huwart; Jorge Abarca‐Quinones; Mylène Dorvillius; Laurence Annet; Frank Peeters; Bernard E. Van Beers is a Medicine article available to read on EtoBox.

What is Transvascular and interstitial transport in rat hepatocellular carcinomas: Dynamic contrast‐enhanced MRI assessment with low‐ and high‐molecular weight agents about?

## Abstract ## Purpose To assess which MRI‐derived kinetic parameters reflect decreased transvascular and interstitial transport when low‐ and high‐molecular‐weight agents are used in rat hepatocellular carcinomas. ## Materials and Methods Dynamic MRI after injection of a low‐molecular‐weight contrast agent of 0.56 kDa (Gd‐DOTA, gadoterate) and two high‐molecular‐weight contrast agents of 6.47 kDa (P792, gadomelitol) and 52 kDa (P717, carboxymethyldextran Gd‐DOTA) was performed in rats with chemically induced hepatocellular carcinomas. The data were analyzed with the Kety compartmental model, the extended Kety compartmental model in which it is assumed that the tissue voxels contain a vascular component, and the St Lawrence and Lee distributed‐parameter model. ## Results The extravascular extracellular space accessible to the contrast agent __v__~__e__~ and the extraction fraction __E__ decreased with increasing molecular weight of the contrast agent. In contrast, the volume transfer constant __Ktrans__ did not differ significantly when low‐ or high‐molecular‐weight agents were used. ## Conclusion In this animal model the results suggest that the accessible extravascular extracellu

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Author

Nicolas Michoux; Laurent Huwart; Jorge Abarca‐Quinones; Mylène Dorvillius; Laurence Annet; Frank Peeters; Bernard E. Van Beers

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)

Published

2008

Language

EN

Field

Medicine (Health Sciences)