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Identification of intestinal-type Barrett's metaplasia by using the intestine-specific protein villin and esophageal brush cytology by Allison J. MacLennan; Mark B. Orringer; David G. Beer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Identification of intestinal-type Barrett's metaplasia by using the intestine-specific protein villin and esophageal brush cytology about?

Villin is an actin-binding cytoskeletal protein required for brush-border formation in the normal small intestinal and renal proximal tubule epithelium. Villin is a marker of cell differentiation in small intestinal and renal cell lineages, and recent studies have shown villin to be highly expressed in 100% of intestinal-type Barrett's metaplasias. This epithelium is the single greatest risk factor for developing esophageal adenocarcinoma and arises when the normal esophageal squamous epithelium is replaced by a small intestine-like columnar epithelium after damage by chronic gastroesophageal reflux. In intestinal-type Barrett's metaplasia, the villin protein exhibits a highly characteristic staining pattern in which strong apical, brush-border staining of columnar epithelial cells is observed. In this study, the ability to identify intestinal metaplastic cells by using this distinct villin staining pattern was examined in endoscopic esophageal brushings from patients with confirmed Barrett's metaplasia. Esophageal brushings from 81% (17 of 21) of patients with Barrett's metaplasia demonstrated individual columnar cells with the characteristic villin staining pattern, whereas all n

Who reads Identification of intestinal-type Barrett's metaplasia by using the intestine-specific protein villin and esophageal brush cytology?

Author

Allison J. MacLennan; Mark B. Orringer; David G. Beer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)

Published

1999

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)