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Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts by Hisayuki Matsunaga; Ryota Hokari; Chie Kurihara; Yoshikiyo Okada; Koichi Takebayashi; Keisuke Okudaira; Chikako Watanabe; Syunsuke Komoto; Mitsuyasu Nakamura; Yoshikazu Tsuzuki; Atushi Kawaguchi; Shigeaki Nagao; Kazuro Itoh; Soichiro Miura is a Medicine article available to read on EtoBox.
What is Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts about?
## Background: Although the immunoregulatory effects of -3 fatty acid and adiponectin have been postulated, their role in intestinal inflammation is controversial. The aim of this study was to determine whether dietary fat intake influences activity of colonic inflammation through modulating this system. Methods: C57BL/6 mice received dextran sulfate sodium for induction of colitis. Mice were fed a control diet, -3 fat-rich diet, -6 fat-rich diet, or saturated fat-rich diet. Some mice were administered a peroxisome proliferator activated receptor-gamma; agonist, pioglitazone. Messenger RNA expression of adiponectin and its receptors were analyzed. Adiponectin expression in colonic mucosa of ulcerative colitis patients was also analyzed. ## Results: The receptors for adiponectin were found to be ubiquitously expressed in epithelial cells, intraepithelial lymphocytes, lamina proprial mononuclear cells, and subepithelial myofibroblasts from colonic tissue, but adiponectin was only expressed in myofibroblasts. Induction of colitis significantly decreased the expression of adiponectin in colonic mucosa. The -3 fat diet group, but not the other fat diet groups, showed exacerbated colitis
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- Author
- Hisayuki Matsunaga; Ryota Hokari; Chie Kurihara; Yoshikiyo Okada; Koichi Takebayashi; Keisuke Okudaira; Chikako Watanabe; Syunsuke Komoto; Mitsuyasu Nakamura; Yoshikazu Tsuzuki; Atushi Kawaguchi; Shigeaki Nagao; Kazuro Itoh; Soichiro Miura
- Publisher
- John Wiley and Sons; Oxford University Press; Oxford University Press (OUP) (ISSN 1078-0998)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)