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Fabry’s disease and stroke: Effectiveness of enzyme replacement therapy (ERT) in stroke prevention, a review with meta-analysis by Sen Sheng; Leihong Wu; Krishna Nalleballe; Rohan Sharma; Aliza Brown; Saritha Ranabothu; Nidhi Kapoor; Sanjeeva Onteddu is a Medicine article available to read on EtoBox.

What is Fabry’s disease and stroke: Effectiveness of enzyme replacement therapy (ERT) in stroke prevention, a review with meta-analysis about?

## Back ground and objective: Fabry's disease, is the most prevalent lysosomal storage disorder and is notorious for its early multi-organ involvement leading to complications, including ischemic strokes and transient ischemic attacks. since 2001, enzyme replacement therapy (ert) has become the mainstay treatment for fabry's patients but the indications are not clearly defined. we did a meta-analysis of the available data to review the benefit of ert for stroke prevention in fabry's patients. ## Methods: A literature search was performed from national center for biotechnology information (ncbi)/pubmed database without restriction of years for systematic review purposes. a systematic review of clinical cohort studies and trials was performed with pooled analysis of proportions. the pooled proportions and the confidence intervals (ci) for stroke recurrence ratio were calculated for both ert treatment group and native treatment groups. ## Result: A total of 7 cohort studies and 2 rcts involving 7513 participants (1471 on ert vs 6042 on native treatment) met inclusion criteria. the pooled proportions analysis showed that the stroke recurrence ratio in the ert treatment group was 8.2% [

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Author

Sen Sheng; Leihong Wu; Krishna Nalleballe; Rohan Sharma; Aliza Brown; Saritha Ranabothu; Nidhi Kapoor; Sanjeeva Onteddu

Publisher

Elsevier Science; Elsevier ; Churchill Livingstone; Elsevier BV (ISSN 0967-5868)

Published

2019

Language

EN

Field

Medicine (Health Sciences)