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What is Pyrrole Chalcones as CYP1 Inhibitors about?
This study reports the synthesis and biological evaluation of twenty-three pyrrole-based chalcones as inhibitors of CYP1 enzymes, which are implicated in cancer prevention and overcoming cisplatin resistance. Notably, compound 3n exhibited potent inhibition of CYP1B1, while compound 3j inhibited both CYP1A1 and CYP1B1, effectively reversing cisplatin resistance in human cells. Molecular modeling studies were conducted to understand the selectivity and potency of these compounds as CYP1 inhibitors.
- Author
- abanish37
- Language
- EN