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Can I read TGF-β Determines the Pro-migratory Potential of bFGF Signaling in Medulloblastoma on EtoBox?
TGF-β Determines the Pro-migratory Potential of bFGF Signaling in Medulloblastoma by Karthiga Santhana Kumar; Anuja Neve; Ana S. Guerreiro Stucklin; Claudia M. Kuzan-Fischer; Elisabeth J. Rushing; Michael D. Taylor; Dimitra Tripolitsioti; Lena Behrmann; Daniel Kirschenbaum; Michael A. Grotzer; Martin Baumgartner is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is TGF-β Determines the Pro-migratory Potential of bFGF Signaling in Medulloblastoma about?
The microenvironment shapes cell behavior and determines metastatic outcomes of tumors. We addressed how microenvironmental cues control tumor cell invasion in pediatric medulloblastoma (MB). We show that bFGF promotes MB tumor cell invasion through FGF receptor (FGFR) in vitro and that blockade of FGFR represses brain tissue infiltration in vivo. TGF-β regulates pro-migratory bFGF function in a context-dependent manner. Under low bFGF, the non-canonical TGF-β pathway causes ROCK activation and cortical translocation of ERK1/2, which antagonizes FGFR signaling by inactivating FGFR substrate 2 (FRS2), and promotes a contractile, non-motile phenotype. Under high bFGF, negative-feedback regulation of FRS2 by bFGF-induced ERK1/2 causes repression of the FGFR pathway. Under these conditions, TGF-β counters inactivation of FRS2 and restores pro-migratory signaling. These findings pinpoint coincidence detection of bFGF and TGF-β signaling by FRS2 as a mechanism that controls tumor cell invasion. Thus, targeting FRS2 represents an emerging strategy to abrogate aberrant FGFR signaling.
Who reads TGF-β Determines the Pro-migratory Potential of bFGF Signaling in Medulloblastoma?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Karthiga Santhana Kumar; Anuja Neve; Ana S. Guerreiro Stucklin; Claudia M. Kuzan-Fischer; Elisabeth J. Rushing; Michael D. Taylor; Dimitra Tripolitsioti; Lena Behrmann; Daniel Kirschenbaum; Michael A. Grotzer; Martin Baumgartner
- Publisher
- Elsevier ; Cell Press; Amsterdam: Elsevier; Research Square; Elsevier BV (ISSN 2211-1247)
- Published
- 2018
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)