Can I read Differential Effects of Eight Metal Ions on Lymphocyte Differentiation Antigens in Vitro on EtoBox?

Differential Effects of Eight Metal Ions on Lymphocyte Differentiation Antigens in Vitro by Isabel Bravo; Graça S. Carvalho; Mário A. Barbosa; Maria de Sousa is a Medicine article available to read on EtoBox.

What is Differential Effects of Eight Metal Ions on Lymphocyte Differentiation Antigens in Vitro about?

In vitro studies were conducted to determine the effects of metal ions known to be released from metallic implants in vivo on the expression of lymphocyte surface antigens. Normal human peripheral blood lymphocytes were exposed to various concentrations of metal ions (Fe3+, Ni2+, Co2+, Mo6+, vt, Cr6+, Cr3+, and Ti3+) for 30 min at 37°C in a 5% COz atmosphere, and then analyzed for their ability to form rosettes with sheep red blood cells. Following this preliminary analysis, lymphocytes were exposed to the metal ions found to inhibit the E-rosette reaction (Fe3+, Ni2+, and Co2+) in order to determine which of the following surface antigens were affected: CD2, CD3, CD4, CD8, CD1, CD22, CD10, and HLA-DR. Our results showed that the in vitro treatment of lymphocytes with Fe3+ or Coz+ caused inhibition of CD2 only, whereas Ni2+ caused inhibition of both CD2 and CD3 antigens. These findings suggest that Fe3+, C o 2 + , and Ni2+ ions may interfere with T cell activation since both CD2 and CD3 are involved in that process.

Who reads Differential Effects of Eight Metal Ions on Lymphocyte Differentiation Antigens in Vitro?

Author

Isabel Bravo; Graça S. Carvalho; Mário A. Barbosa; Maria de Sousa

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

1990

Language

EN

Field

Medicine (Health Sciences)