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Pentamidine-loaded poly(D,L-lactide) nanoparticles: Adsorption and drug release by Muriel Paul; Abdelkader Laatiris; Hatem Fessi; Barbara Dufeu; Rémy Durand; Michèle Deniau; Alain Astier is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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This work describes the loading capacity of poly(D,L-lactide) nanoparticles, the factors influencing pentamidine release, and the cytotoxicity of nanoparticles. The nanoprecipitation method was used to prepare pentamidine-loaded poly(D,L-lactide) nanoparticles. Various concentrations of pentamidine base and polymer were tested. The influence of the dilution, temperature, and ionic strength was evaluated. The cytotoxicity on J 774 cells of unloaded nanoparticles, pentamidine-loaded nanoparticles, and pentamidine isethionate were tested. The percentage of binding decreased significantly with drug load. A nonlinear increase in drug uptake per unit mass of polymer with the equilibrium pentamidine concentration was found. A Langmuir-type sorption was suggested (r = 0.998). 390 μg/ml was found to be the highest level of drug incorporation. The increase of polymer concentration did not improve the pentamidine fixation yield. The increase in temperature or buffer molarity induced a significant release of pentamidine. The increase in dilution also induced an increase in release of pentamidine. The cytotoxicity of pentamidine-loaded nanoparticles and unloaded nanoparticles was superimposable

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Author

Muriel Paul; Abdelkader Laatiris; Hatem Fessi; Barbara Dufeu; Rémy Durand; Michèle Deniau; Alain Astier

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0272-4391)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)