Can I read p53 Immunostaining and image cytometry DNA analysis in precancerous and cancerous squamous epithelial lesions of the larynx on EtoBox?

p53 Immunostaining and image cytometry DNA analysis in precancerous and cancerous squamous epithelial lesions of the larynx by Eva Munck-Wikland; Richard Kuylenstierna; Johan Lindholm; Gert Auer is a Medicine article available to read on EtoBox.

What is p53 Immunostaining and image cytometry DNA analysis in precancerous and cancerous squamous epithelial lesions of the larynx about?

Background: Squamous epithelial cancer can develop from progressive epithelial changes connoted dysplasias. Histopathologic evaluation/grading of these lesions is difficult and gives poor information concerning the risk for progression to cancer. Squamous cell carcinoma of the head and neck (SCCHN) frequently show p53 alteration and DNA-ploidy aberration. Could these markers be used as indicators for malignancy risk in the larynx? Methods: Immunohistochemical staining (IHC), with the CM-l antibody against p53, and image cytometry (ICM) DNA analysis were performed in 60 lesions from 12 patients-and 21 controls-who were initially seen with laryngeal lesions prior to cancer in situ (cis) or invasive cancer diagnosis at the same site. Results: All but one of the invasive cancers, and 77% of the lesions which preceded cancer or cancer in situ, showed positive p53 immunostaining, as compared with only 10% of the controls. All but one of the invasive cancer lesions, and 77% of the precan-Presented at Fourth Research Workshop on the Biology, Prevention, and

Who reads p53 Immunostaining and image cytometry DNA analysis in precancerous and cancerous squamous epithelial lesions of the larynx?

Author

Eva Munck-Wikland; Richard Kuylenstierna; Johan Lindholm; Gert Auer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1043-3074)

Published

1997

Language

EN

Field

Medicine (Health Sciences)