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Nutritional Metabolomics and the Classification of Dietary Biomarker Candidates: A Critical Review by Talha Rafiq; Sandi M Azab; Koon K Teo; Lehana Thabane; Sonia S Anand; Katherine M Morrison; Russell J de Souza; Philip Britz-McKibbin is a Medicine article available to read on EtoBox.
What is Nutritional Metabolomics and the Classification of Dietary Biomarker Candidates: A Critical Review about?
ABSTRACT Recent advances in metabolomics allow for more objective assessment of contemporary food exposures, which have been proposed as an alternative or complement to self-reporting of food intake. However, the quality of evidence supporting the utility of dietary biomarkers as valid measures of habitual intake of foods or complex dietary patterns in diverse populations has not been systematically evaluated. We reviewed nutritional metabolomics studies reporting metabolites associated with specific foods or food groups; evaluated the interstudy repeatability of dietary biomarker candidates; and reported study design, metabolomic approach, analytical technique(s), and type of biofluid analyzed. A comprehensive literature search of 5 databases (PubMed, EMBASE, Web of Science, BIOSIS, and CINAHL) was conducted from inception through December 2020. This review included 244 studies, 169 (69%) of which were interventional studies (9 of these were replicated in free-living participants) and 151 (62%) of which measured the metabolomic profile of serum and/or plasma. Food-based metabolites identified in ≥1 study and/or biofluid were associated with 11 food-specific categories or dietary p
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- Author
- Talha Rafiq; Sandi M Azab; Koon K Teo; Lehana Thabane; Sonia S Anand; Katherine M Morrison; Russell J de Souza; Philip Britz-McKibbin
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)