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Can I read Dual Role of Glutathione as a Reducing Agent and Cu-Ligand Governs the ROS Production by Anticancer Cu-Thiosemicarbazone Complexes on EtoBox?
Dual Role of Glutathione as a Reducing Agent and Cu-Ligand Governs the ROS Production by Anticancer Cu-Thiosemicarbazone Complexes by Alessandra G. Ritacca; Enrico Falcone; Iman Doumi; Bertrand Vileno; Peter Faller; Emilia Sicilia is a Chemistry article available to read on EtoBox.
What is Dual Role of Glutathione as a Reducing Agent and Cu-Ligand Governs the ROS Production by Anticancer Cu-Thiosemicarbazone Complexes about?
α-Pyridyl thiosemicarbazones (TSC) such as Triapine (3AP) and Dp44mT are a promising class of anticancer agents. Contrary to Triapine, Dp44mT showed a pronounced synergism with Cu II , which may be due to the generation of reactive oxygen species (ROS) by Dp44mT-bound Cu II ions. However, in the intracellular environment, Cu II complexes have to cope with glutathione (GSH), a relevant Cu II reductant and Cu Ichelator. Here, aiming at rationalizing the different biological activity of Triapine and Dp44mT, we first evaluated the ROS production by their Cu II -complexes in the presence of GSH, showing that Cu II -Dp44mT is a better catalyst than Cu II -3AP. Furthermore, we performed density functional theory (DFT) calculations, which suggest that a different hard/soft character of the complexes could account for their different reactivity with GSH.
Who reads Dual Role of Glutathione as a Reducing Agent and Cu-Ligand Governs the ROS Production by Anticancer Cu-Thiosemicarbazone Complexes?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Alessandra G. Ritacca; Enrico Falcone; Iman Doumi; Bertrand Vileno; Peter Faller; Emilia Sicilia
- Publisher
- American Chemical Society (ACS)
- Published
- 2023
- Language
- EN
- Field
- Chemistry (Physical Sciences)