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Can I read Reduced response to Epstein–Barr virus antigens by T-cells in systemic lupus erythematosus patients on EtoBox?
Reduced response to Epstein–Barr virus antigens by T-cells in systemic lupus erythematosus patients by Draborg, Anette Holck; Jacobsen, Søren; Westergaard, Marie; Mortensen, Shila; Larsen, Janni Lisander; Houen, Gunnar; Duus, Karen is a Medicine article available to read on EtoBox.
What is Reduced response to Epstein–Barr virus antigens by T-cells in systemic lupus erythematosus patients about?
## Objective Epstein–Barr virus (EBV) has for long been associated with systemic lupus erythematosus (SLE). In this study, we investigated the levels of latent and lytic antigen EBV-specific T-cells and antibodies in SLE patients. ## Methods T cells were analyzed by flow cytometry and antibodies were analyzed by enzyme-linked immunosorbent assay. ## Results SLE patients showed a significantly reduced number of activated (CD69) T-cells upon ex vivo stimulation with EBV nuclear antigen (EBNA) 1 or EBV early antigen diffuse (EBV-EA/D) in whole blood samples compared with healthy controls. Also, a reduced number of T-cells from SLE patients were found to produce interferon-γ upon stimulation with these antigens. Importantly, responses to a superantigen were normal in SLE patients. Compared with healthy controls, SLE patients had fewer EBV-specific T-cells but higher titres of antibodies against EBV. Furthermore, an inverse correlation was revealed between the number of lytic antigen EBV-specific T-cells and disease activity of the SLE patients, with high-activity SLE patients having fewer T-cells than low-activity SLE patients. ## Conclusions These results indicate a limited or a defec
Who reads Reduced response to Epstein–Barr virus antigens by T-cells in systemic lupus erythematosus patients?
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- Author
- Draborg, Anette Holck; Jacobsen, Søren; Westergaard, Marie; Mortensen, Shila; Larsen, Janni Lisander; Houen, Gunnar; Duus, Karen
- Publisher
- BMJ; BMJ Publishing Group; London: BMJ (ISSN 2053-8790)
- Published
- 2014
- Language
- EN
- Field
- Medicine (Health Sciences)