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Population pharmacokinetics of amikacin in Korean adult patients by K PARK; M PARK; Y SONG; H KIM; E NOH; K KIM is a Medicine article available to read on EtoBox.

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BACKGROUND: To determine demographic and clinical covariates that affect amikacin pharmacokinetic parameters in Korean clinical population METHODS: For 200 Korean adult patients (115 men and 85 women), blood samples were drawn at the trough and peak steadystate plasma concentrations after multiple infusions of the drug. Amikacin concentration was analyzed by Fluorescence Polarization Immunoassay. Using one-compartment model, the clearance and volume of distribution of amikacin and their relevance to various covariates (creatinine clearance, sex, ward (intensive care unit vs general), disease diagnosed) were estimated by a nonlinear mixed effect model using the NONMEM software, with a stepwise addition method for covariate selection. RESULTS: Creatinine clearance had the most significant influence on amikacin pharmacokinetics (p ϽϽ 0.0001 for clearance, p Ͻ0.0001 for volume of distribution). In particular, amikacin clearance was significantly influenced by ward (1.37 (1.18 -1.56) for intensive care unit, 2.24 (2.09 -2.39) for general) and urinary tract infection (UTI) (1.44 (0.85-2.03) for UTI, 2.13 (1.97-2.29) for no UTI), with numbers denoting mean values (95% confidence interval)

Who reads Population pharmacokinetics of amikacin in Korean adult patients?

Author

K PARK; M PARK; Y SONG; H KIM; E NOH; K KIM

Publisher

Nature Publishing Group; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley; Springer Science and Business Media LLC; Research Square (ISSN 0009-9236)

Published

2005

Language

EN

Field

Medicine (Health Sciences)