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Red Blood Cell Morphology in Patients with β-Thalassemia Minor by Carolin Körber; Albert Wölfler; Manfred Neubauer; Christoph Robier is a Medicine article available to read on EtoBox.

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## Abstract ## Background: A systematic analysis of the occurrence of red blood cell (RBC) abnormalities in β-thalassemia minor has not been performed to date. This study aimed to identify and quantify the frequency of RBC abnormalities in patients with β-thalassemia minor. ## Methods: We examined blood smears of 33 patients with β-thalassemia minor by light microscopy for the occurrence of 15 defined RBC abnormalities. In the case of positivity, the abnormal cells/20 high power fields (HPF) at 1000-fold magnification were counted. ## Results: Anisocytosis, poikilocytosis and target cells (median 42/20 HPF) were observed in all, and ovalocytes in 32 (96.9%, median 10/20 HPF) subjects. Dacryocytes (81.8%), stomatocytes (81.8%, median 10/20 HPF), elliptocytes (75.8%), cells with basophilic stippling (72.7%) and irregularly contracted cells (63.6%) were frequently, and schistocytes (15.2%), bite cells (6%) and pincer cells (3%) were occasionally found. ## Conclusions: Morphological abnormalities of erythrocytes are common in peripheral blood (PB) smears of patients with β-thalassemia minor. In this study, anisocytosis, poikilocytosis and target cells were apparent in all, and ovalocyt

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Author

Carolin Körber; Albert Wölfler; Manfred Neubauer; Christoph Robier

Publisher

Walter de Gruyter GmbH

Published

2016

Language

EN

Field

Medicine (Health Sciences)