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Can I read Chromogranin A‐positive hormone‐negative endocrine cells in pancreas in human pregnancy on EtoBox?
Chromogranin A‐positive hormone‐negative endocrine cells in pancreas in human pregnancy by Moin, Abu Saleh Md ;Zeng, Kylie ;Rizza, Robert A. ;Dhawan, Sangeeta ;Butler, Alexandra E. is a Medicine article available to read on EtoBox.
What is Chromogranin A‐positive hormone‐negative endocrine cells in pancreas in human pregnancy about?
## Abstract ## Introduction We sought to determine whether chromogranin A‐positive hormone‐negative (CPHN) endocrine cells are increased in the pancreas of pregnant women, offering potential evidence in support of neogenesis. ## Methods Autopsy pancreata from pregnant women (__n__ = 14) and age‐matched non‐pregnant control women (__n__ = 9) were obtained. Staining of pancreatic sections for chromogranin A, insulin and a cocktail of glucagon, somatostatin, pancreatic polypeptide and ghrelin was undertaken, with subsequent evaluation for CPHN cell frequency. ## Results The frequency of clustered β‐cells was increased in pregnant compared to non‐pregnant subjects (46.6 ± 5.0 vs. 31.8 ± 5.0% clustered β‐cells of total clustered endocrine cells, pregnant vs. non‐pregnant, __p__ < .05). Frequency of endocrine cocktail cells was lower in pregnant women than non‐pregnant women (36.2 ± 4.0 vs. 57.0 ± 6.8% clustered endocrine cocktail cells of total clustered endocrine cells, pregnant vs. non‐pregnant, __p__ < .01). No difference in frequency of CPHN cells was found in islets, nor in clustered or single cells scattered throughout the exocrine pancreas, between pregnant and non‐pregnant women
Who reads Chromogranin A‐positive hormone‐negative endocrine cells in pancreas in human pregnancy?
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- Author
- Moin, Abu Saleh Md ;Zeng, Kylie ;Rizza, Robert A. ;Dhawan, Sangeeta ;Butler, Alexandra E.
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)