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Immunohistochemical Study of Myoglobin and Oxidative Injury-related Markers in the Kidney of Methamphetamine Abusers by Akiko Ishigami; Itsuo Tokunaga; Takako Gotohda; Shin-ichi Kubo is a Medicine article available to read on EtoBox.

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It is known that methamphetamine (MA) causes rhabdomyolysis, myoglobinuria, and acute renal failure. We conducted an immunohistochemical study on the kidney of 22 forensic autopsy cases in which MA had been detected. Myoglobin was positive in 17 cases. The concentration of the blood MA in the myoglobin-positive cases (8.39 ^3.43 mmol/dl) was higher than -negative cases (0.198 ^0.076 mmol/dl). And, the 70 kDa heat shock protein (HSP70), 8-hydroxy-2 0 -deoxyguanosine (8-OH-dG), 4-hydroxy-2-nonenal (4-HNE), and Cu/Zn superoxide dismutase (SOD) were also stained positively in five, ten, 11, nine cases of examined, respectively. In addition, 80% of HSP70-positive cases were myoglobin-positive. Myoglobin was also observed in 60% of 8-OH-dG-positive, in 82% of 4-HNE-positive, and in 78% of SOD-positive cases, respectively. Therefore, myoglobin rather than MA itself might induce oxidative damage. From these results, it was considered that MA abuse had caused the skeletal muscle damage before death. In forensic autopsy cases of drug abusers, the antemortem situation is not often known. The present research suggested that in addition to the measurement of the concentration of MA, immunohisto

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Author

Akiko Ishigami; Itsuo Tokunaga; Takako Gotohda; Shin-ichi Kubo

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1344-6223)

Published

2003

Language

EN

Field

Medicine (Health Sciences)