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Brain PBPK Model for CSF Drug Concentrations by Walaa Yousef is a document available to read on EtoBox.
What is Brain PBPK Model for CSF Drug Concentrations about?
The document describes the development of a 4-compartment permeability-limited brain (4Brain) model within a whole-body physiologically-based pharmacokinetic model. The 4Brain model includes compartments for brain blood, brain mass, cranial cerebrospinal fluid, and spinal cerebrospinal fluid. It accounts for physiology and transporters at the blood-brain and blood-CSF barriers. The model was verified using in vitro data and clinical observations for paracetamol and phenytoin. Simulated results matched obser
- Author
- Walaa Yousef
- Language
- EN