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Urinary phthalate exposures and risk of breast cancer: the Multiethnic Cohort study by Anna H. Wu; Adrian A. Franke; Lynne R. Wilkens; Chiuchen Tseng; Shannon M. Conroy; Yuqing Li; Linda M. Polfus; Mindy De Rouen; Christian Caberto; Christopher Haiman; Daniel O. Stram; Loïc Le Marchand; Iona Cheng is a Medicine article available to read on EtoBox.
What is Urinary phthalate exposures and risk of breast cancer: the Multiethnic Cohort study about?
## Abstract ## Background The epidemiologic evidence from observational studies on breast cancer risk and phthalates, endocrine disrupting chemicals, has been inconsistent. In the only previous study based on pre-diagnostic urinary phthalates and risk of breast cancer, results were null in mostly white women. ## Methods We examined the association between pre-diagnostic urinary phthalates and breast cancer in a nested case-control study within the Multiethnic Cohort (MEC) study, presenting the first data from five major racial/ethnic groups in the USA. We measured 10 phthalate metabolites and phthalic acid, using a sensitive liquid chromatography mass spectrometry assay on 1032 women with breast cancer (48 African Americans, 77 Latinos, 155 Native Hawaiians, 478 Japanese Americans, and 274 Whites) and 1030 matched controls. Conditional logistic regression was used to examine risk with individual metabolites and ratios of primary (MEHP, mono-2-ethylhexyl-phthalate) to secondary (MEHHP, mono(2-ethyl-5-hydroxyhexyl); MEOHP, mono(2-ethyl-5-oxohexy)) metabolites of di-2-ethylhexyl phthalate (DEHP), a widely used plasticizer. In addition, we investigated risk associations with high (∑HMW
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- Author
- Anna H. Wu; Adrian A. Franke; Lynne R. Wilkens; Chiuchen Tseng; Shannon M. Conroy; Yuqing Li; Linda M. Polfus; Mindy De Rouen; Christian Caberto; Christopher Haiman; Daniel O. Stram; Loïc Le Marchand; Iona Cheng
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)