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What is JMM 002153 about?
This study investigates the strain-specific persistence of Burkholderia cenocepacia in the C3HeB/FeJ mouse model, which is characterized by impaired macrophage-mediated immunity. The findings reveal that C3HeB/FeJ mice are particularly susceptible to sustained pulmonary infection by B. cenocepacia AU0728, with significant bacterial persistence and ineffective immune responses. The research highlights the role of macrophage dysfunction in chronic infections and establishes the C3HeB/FeJ model as a valuable t
- Author
- d4rkgr455
- Language
- EN