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Selected recombinant Aspergillus fumigatus allergens bind specifically to IgE in ABPA by Kurup; Banerjee; Hemmann; Greenberger; Blaser; Crameri is a Medicine article available to read on EtoBox.

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## Background: Allergic bronchopulmonary aspergillosis (abpa) is a hypersensitivity lung disease resulting from exposure to aspergillus fumigatus allergens. patients with abpa show elevated aspergillus-specific serum ige, a major criterion used in the diagnosis of the disease. crude culture filtrate and mycelial antigens have been used widely to demonstrate ige antibody to aspergillus in the sera of patients. while these antigens have been useful in the diagnosis of abpa, occasionally they present inconsistency in their reactivity and lack of specificity. although in recent years, a number of purified a. fumigatus allergens have been produced by molecular cloning, no attempt was made to evaluate them systematically. ## Objective: To evaluate the recombinant proteins from a. fumigatus for their ige antibody binding, we studied sera from abpa patients and controls by antigen specific enzyme linked immunosorbent assay (elisa). ## Methods: Recombinant aspergillus allergens asp f 1, f 2, f 3, f 4, and f 6 were studied for their specific binding to ige in the sera of abpa patients, a. fumigatus skin prick test positive asthmatics, and normal controls from the usa and switzerland. the ser

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Author

Kurup; Banerjee; Hemmann; Greenberger; Blaser; Crameri

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0954-7894)

Published

2000

Language

EN

Field

Medicine (Health Sciences)