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Can I read Discovery of a novel olefin derivative as a highly potent and selective acetyl-CoA carboxylase 2 inhibitor with in vivo efficacy on EtoBox?
Discovery of a novel olefin derivative as a highly potent and selective acetyl-CoA carboxylase 2 inhibitor with in vivo efficacy by Yuji Nishiura; Akira Matsumura; Naotake Kobayashi; Atsuyuki Shimazaki; Shingo Sakamoto; Naohisa Kitade; Yutaka Tonomura; Akira Ino; Takayuki Okuno is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Discovery of a novel olefin derivative as a highly potent and selective acetyl-CoA carboxylase 2 inhibitor with in vivo efficacy about?
Novel acetyl-CoA carboxylase 2 (ACC2) selective inhibitors were identified by the conversion of the alkyne unit of A-908292 to the olefin linker. Modification of the center and left part of the lead compound 1b improved the ACC2 inhibitory activity and CYP450 inhibition profile, and afforded a highly selective ACC2 inhibitor 2e which showed in vivo efficacy in C57BL/6 mice.
Who reads Discovery of a novel olefin derivative as a highly potent and selective acetyl-CoA carboxylase 2 inhibitor with in vivo efficacy?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yuji Nishiura; Akira Matsumura; Naotake Kobayashi; Atsuyuki Shimazaki; Shingo Sakamoto; Naohisa Kitade; Yutaka Tonomura; Akira Ino; Takayuki Okuno
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2018
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)