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P1892Asymmetric and symmetric dimethylarginine in atrial fibrillation progression and recurrence by P Buettner; E Schwedhelm; G Hindricks; R H Boeger; H Thiele; J Kornej is a Medicine article available to read on EtoBox.

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## Abstract ## Background Asymmetric and symmetric dimethylarginine (ADMA and SDMA) are post-translationally modified amino-acids that inhibit nitric oxide (NO) production and have been associated with cardiovascular events and death. Recently, an association of ADMA with atrial fibrillation (AF) incidence and prevalence has been described. In this study we analyzed the association of ADMA and SDMA with the progression and recurrence of AF. ## Methods In total, 254 patients (64±11 years, 67% males, BMI 29±8 kg/m2, 53% paroxysmal AF, 27% low voltage areas (LVA)) undergoing first AF ablation were included into analyses. LVA were determined using high-density maps and defined as <0.5 mV. AF progression was defined as paroxysmal AF (PAF) with/without LVA and continuous AF (CAF) with/without LVA. AF recurrences were defined as any atrial arrhythmia occurring after ablation 3 to 18 months. Blood plasma samples were collected before catheter ablation and at follow-up. ADMA and SDMA were measured in plasma samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS). ## Results While no differences were detected for ADMA, the SDMA plasma concentrations were significantly higher in

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Author

P Buettner; E Schwedhelm; G Hindricks; R H Boeger; H Thiele; J Kornej

Publisher

Oxford University Press; Oxford University Press (OUP); Elsevier BV (ISSN 0195-668X)

Published

2019

Language

EN

Field

Medicine (Health Sciences)