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Can I read Efficient Access to New Chemical Space Through Flow—Construction of Druglike Macrocycles Through Copper‐Surface‐Catalyzed Azide–Alkyne Cycloaddition Reactions on EtoBox?
Efficient Access to New Chemical Space Through Flow—Construction of Druglike Macrocycles Through Copper‐Surface‐Catalyzed Azide–Alkyne Cycloaddition Reactions by Andrew R. Bogdan; Keith James is a Chemistry article available to read on EtoBox.
What is Efficient Access to New Chemical Space Through Flow—Construction of Druglike Macrocycles Through Copper‐Surface‐Catalyzed Azide–Alkyne Cycloaddition Reactions about?
## Abstract A series of 12‐ to 22‐membered macrocycles, with druglike functionality and properties, have been generated by using a simple and efficient copper‐catalyzed azide–acetylene cycloaddition reaction, conducted in flow in high‐temperature copper tubing, under environmentally friendly conditions. The triazole‐containing macrocycles have been generated in up to 90 % yield in a 5 min reaction, without resorting to the high‐dilution conditions typical of macrocyclization reactions. This approach represents a very efficient method for constructing this important class of molecules, in terms of yield, concentration, and environmental considerations.
Who reads Efficient Access to New Chemical Space Through Flow—Construction of Druglike Macrocycles Through Copper‐Surface‐Catalyzed Azide–Alkyne Cycloaddition Reactions?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Andrew R. Bogdan; Keith James
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0947-6539)
- Published
- 2010
- Language
- EN
- Field
- Chemistry (Physical Sciences)