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High-performance Liquid Chromatography-electrospray Ionisation-tandem Mass Spectrometry for the Analysis of 1,2,3,4-Tetrahydro-β-carboline Derivatives by B. Gutsche; M. Herderich is a Chemistry article available to read on EtoBox.

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A rapid and sensitive method is described for the detection of 1,2,3,4-tetrahydro-13-carboline-3-carboxylic acid, 1-methyl-1,2,3,4-tetrahydro-13-carboline-3-carboxylic acid and 1-methyl-l,2,3,4-tetrahydro-13-carboline by electrospray ionization tandem mass spectrometry coupled to liquid chromatography. In combination with selected reaction monitoring (SRM) detection limits of 3 ng ml-~ (ca. 75 fmol on column) were established by the use of model solutions. Due to the excellent selectivity and sensitivity of SRM no sample preparation step was required prior to analysis of food samples. In addition, any artifactual formation of tetrahydro-13-carbolines could be excluded. Application of the method revealed that all food samples analyzed contained both tetrahydro-13-carboline-carboxylic acids at ng ml ' to Ixg ml-~ concentrations, whereas 1-methyl-1,2,3,4-tetrahydro-[3-carboline was identified in most samples as a minor constituent.

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Author

B. Gutsche; M. Herderich

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)

Published

1997

Language

EN

Field

Chemistry (Physical Sciences)