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Enhancement of repair of radiation induced DNA strand breaks in human cells by Ganoderma mushroom polysaccharides by Thulasi G. Pillai; C.K.K. Nair; K.K. Janardhanan is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Enhancement of repair of radiation induced DNA strand breaks in human cells by Ganoderma mushroom polysaccharides about?

The DNA repair ability of a cell is vital to the integrity of its genome and thus to its normal functioning and that of the organism. The repair-enhancing property of polysaccharides isolated from Ganoderma lucidum which belongs to the polyporaceae family was determined by comet assay in human peripheral blood leukocytes. Comet parameters were studied at 2 Gy gamma irradiation with 15 min intervals. The comet parameters after 2 Gy exposures to c-radiation were reduced to nearly normal levels after 120 min of exposure. The polysaccharides from G. lucidum enhance the repair process, which is a promising approach for protection from radiation exposure, but a detailed study of the molecular mechanism is needed for further application.

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Author

Thulasi G. Pillai; C.K.K. Nair; K.K. Janardhanan

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0308-8146)

Published

2010

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)