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Nutrition, One-carbon Metabolism and Arsenic Methylation by Ahlam Abuawad; Anne K. Bozack; Roheeni Saxena; Mary V. Gamble is a Environmental Science article available to read on EtoBox.

What is Nutrition, One-carbon Metabolism and Arsenic Methylation about?

Exposure to arsenic (As) is a major public health concern globally. Inorganic As (InAs) undergoes hepatic methylation to form monomethyl (MMAs)- and dimethyl (DMAs)-arsenical species, facilitating urinary As elimination. MMAs is considerably more toxic than either InAs or DMAs, and a higher proportion of MMAs in urine has been associated with risk for a wide range of adverse health outcomes. Efficiency of As methylation differs substantially between species, between individuals, and across populations. One-carbon metabolism (OCM) is a biochemical pathway that provides methyl groups for the methylation of As, and is influenced by folate and other micronutrients, such as vitamin B, choline, betaine and creatine. A growing body of evidence has demonstrated that OCM-related micronutrients play a critical role in As methylation. This review will summarize observational epidemiological studies, interventions, and relevant experimental evidence examining the role that OCM-related micronutrients have on As methylation, toxicity of As, and risk for associated adverse health-related outcomes. There is fairly robust evidence supporting the impact of folate on As methylation, and some evidence

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Author

Ahlam Abuawad; Anne K. Bozack; Roheeni Saxena; Mary V. Gamble

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Environmental Science (Life Sciences)