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Surgical Site Infection Prevention and Management in Immunocompromised Patients: a Systematic Review of the Literature by Coccolini, Federico (author);Improta, Mario (author);Cicuttin, Enrico (author);Catena, Fausto (author);Sartelli, Massimo (author);Bova, Raffaele (author);de’ Angelis, Nicola (author);Gitto, Stefano (author);Tartaglia, Dario (author);Cremonini, Camilla (author);Ordonez, Carlos (author);Baiocchi, Gian Luca (author);Chiarugi, Massimo (author) is a Medicine article available to read on EtoBox.

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## Background Immunocompromised patients are at higher risk of surgical site infection and wound complications. However, optimal management in the perioperative period is not well established. Present systematic review aims to analyse existing strategies and interventions to prevent and manage surgical site infections and other wound complications in immunocompromised patients. ## Methods A systematic review of the literature was conducted. ## Results Literature review shows that partial skin closure is effective to reduce SSI in this population. There is not sufficient evidence to definitively suggest in favour of prophylactic negative pressure wound therapy. The use of mammalian target of rapamycin (mTOR) and calcineurin inhibitors (CNI) in transplanted patient needing ad emergent or undeferrable abdominal surgical procedure must be carefully and multidisciplinary evaluated. The role of antibiotic prophylaxis in transplanted patients needs to be assessed. ## Conclusion Strict adherence to SSI infection preventing bundles must be implemented worldwide especially in immunocompromised patients. Lastly, it is necessary to elaborate a more widely approved definition of immunocompromis

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Author

Coccolini, Federico (author);Improta, Mario (author);Cicuttin, Enrico (author);Catena, Fausto (author);Sartelli, Massimo (author);Bova, Raffaele (author);de’ Angelis, Nicola (author);Gitto, Stefano (author);Tartaglia, Dario (author);Cremonini, Camilla (author);Ordonez, Carlos (author);Baiocchi, Gian Luca (author);Chiarugi, Massimo (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)