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Can I read Use of Non-steroidal Anti-inflammatory Drugs in Pregnancy: Impact on the Fetus and Newborn on EtoBox?
Use of Non-steroidal Anti-inflammatory Drugs in Pregnancy: Impact on the Fetus and Newborn by Roberto Antonucci; Marco Zaffanello; Elisabetta Puxeddu; Annalisa Porcella; Laura Cuzzolin; Maria Dolores Pilloni; Vassilios Fanos is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is Use of Non-steroidal Anti-inflammatory Drugs in Pregnancy: Impact on the Fetus and Newborn about?
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed in pregnancy to treat fever, pain and inflammation. Indications for chronic use of these agents during pregnancy are inflammatory bowel or chronic rheumatic diseases. Since the seventies, NSAIDs have been used as effective tocolytic agents: indomethacin has been the reference drug, delaying delivery for at least 48 hours and up to 7-10 days. Additionally, self-medication with NSAIDs is practiced by pregnant women. NSAIDs given to pregnant women cross the placenta and may cause embryo-fetal and neonatal adverse effects, depending on the type of agent, the dose and duration of therapy, the period of gestation, and the time elapsed between maternal NSAID administration and delivery. These effects derive from the action mechanisms of NSAIDs (mainly inhibition of prostanoid activity) and from the physiological changes in drug pharmacokinetics occurring during pregnancy. Increased risks of miscarriage and malformations are associated with NSAID use in early pregnancy. Conversely, exposure to NSAIDs after 30 weeks' gestation is associated with an increased risk of premature closure of the fetal ductus arteriosus and ol
Who reads Use of Non-steroidal Anti-inflammatory Drugs in Pregnancy: Impact on the Fetus and Newborn?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- Roberto Antonucci; Marco Zaffanello; Elisabetta Puxeddu; Annalisa Porcella; Laura Cuzzolin; Maria Dolores Pilloni; Vassilios Fanos
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2012
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)